From drug candidate optimization to Patient Proof of Concept (PoC), PhInc. Modeling is at your side to design your development and supervise its good execution. Based on Model-Informed Drug Development, we help you increase the confidence in decision making and reduces cycle time of your development.

Below are all our services and fields of expertise:

Model based drug development

We offer consultancy and operational management services to bridge the gap between therapeutic lead identification to the clinical stage and to the patient PoC.

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Pharmacokinetics Statistics

Our pharmacokineticists provide precise analysis of data, whatever the purpose of your pharmacokinetic (PK) studies. We cover all PK analysis requirements.

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Modeling & Simulation

Modeling and Simulation (M&S) is a combination of tools to optimize your clinical development. These techniques are used to make the most of the clinical studies data and make the best predictions and simulations.

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Physiologically based Pharmacokinetic modeling

Physiologically Based PharmacoKinetic (PBPK) modeling is a mechanistic approach to predict the absorption, distribution, metabolism and excretion of drugs.

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QT / QTc Analysis (TQT) for cardiac safety

Expert in the use of concentration-response modeling approach to document QT-liability through intensive ECG monitoring from first-in-human studies to ICH E14 dedicated TQT study

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Guiding dose selection

Inadequate dose selection for confirmatory trials is currently still one of the most challenging issues in drug development, as illustrated by high rates of late‐stage attritions in clinical development.

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Filling for health agencies

PhInc. Modeling provides high-quality, regulatory-compliant PK/PD analyses and modeling for regulatory submission packages.

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Target-Mediated Drug Disposition

Successful development of Biologics requires accurate prediction of human exposure.

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Montreal International
GMP - Groupe de Métabolisme et Pharmacocinétique